Many of the bacteria of the most common diseases, such as pneumonia, are becoming resistant to antibiotics and this already represents a serious global problem.
From the Department of Biochemistry and Molecular Biology of the University of Córdoba (UCO) An investigation has been started to determine whether rhodomirtone extracted from an Asian plant is effective in combating the pneumonia-causing pneumonia.
Why do bacteria become resistant?
The cause is natural selection, which makes the simple use of antibiotics to fight a species of pathogens make them, in the long run, develop resistance to them.
In any case, antibiotics that are effective today may not be effective in 40 or 50 years.
Rhodomirtone as a possible solution
Rhodomirtone is a molecule that is extracted from a Southeast Asian plant known as 'Rhodomyrtus tormentosa' and whose effect had been tested on 'Gram-positive' bacteria by a research group from Thailand. Given the knowledge of the antimicrobial properties of the molecule, the scientists decided to go a step further and study the possible antibiotic effect on strains of pneumococcus, the bacterium responsible for diseases such as pneumonia, meningitis, bronchitis or sinusitis.
The results are encouraging, the substance was found to be effective in pneumococcus and the amount necessary to cause the death of the bacteria or inhibit its growth was determined.
In order to ensure the functioning of rodomirtone and to have a deeper knowledge about it, with a view to its future use, the research led to the search for its molecular mechanism.
According to research, rhodomirtone is an effective antibiotic on pneumococcus. In addition, clues have been obtained of its molecular mechanism of action, which works by the reduction or total elimination of the capsule of the pathogen.
Mitsuwan, W; Olaya-Abril, A; Calderon-Santiago, M; Jimenez-Munguia, I; Gonzalez-Reyes, JA; Priego-Capote, F; Voravuthikunchai, SP; Rodriguez-Ortega, MJ. Integrated proteomic and metabolomic analysis reveals that rhodomyrtone reduces the capsule in Streptococcus pneumonia. SCIENTIFIC REPORTS.
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